2017
Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice
Yang X, Wang Q, Pang Z, Pan M, Zhang W. Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice. Pharmaceutical Biology 2017, 55: 1207-1214. PMID: 28248545, PMCID: PMC6130443, DOI: 10.1080/13880209.2016.1278454.Peer-Reviewed Original ResearchConceptsHigh-fat dietAdipose tissueC57BL/6 miceFat dietFSH treatmentBody weightMRNA expressionAdipose tissue inflammationMolecular targetsLipid metabolism disordersObese mouse modelHepatic triglyceride accumulationEffect of FSHTNFα mRNA expressionPPARα mRNA expressionRegulation of PPARγBody weight gainPPARγ protein levelsPotential molecular targetsPPARα gene expressionFSH administrationMacrophage infiltrationTissue inflammationCholesterol levelsMetabolism disorders
2006
FSH Directly Regulates Bone Mass
Sun L, Peng Y, Sharrow A, Iqbal J, Zhang Z, Papachristou D, Zaidi S, Zhu L, Yaroslavskiy B, Zhou H, Zallone A, Sairam M, Kumar T, Bo W, Braun J, Cardoso-Landa L, Schaffler M, Moonga B, Blair H, Zaidi M. FSH Directly Regulates Bone Mass. Cell 2006, 125: 247-260. PMID: 16630814, DOI: 10.1016/j.cell.2006.01.051.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone and BonesBone ResorptionCell DifferentiationCells, CulturedEnzyme ActivationEstrogensExtracellular Signal-Regulated MAP KinasesFemaleFollicle Stimulating HormoneGTP-Binding Protein alpha Subunit, Gi2HumansHypogonadismMiceMice, Inbred C57BLMice, KnockoutNF-kappa BOsteoclastsOsteoporosisProtein SubunitsProto-Oncogene Proteins c-aktReceptors, FSHSignal TransductionConceptsHypogonadal bone lossFSH receptorBone lossDeclining estrogen levelsAction of FSHEffect of FSHNormal ovarian functionGlobal public health problemSevere hypogonadismPublic health problemPostmenopausal osteoporosisFSH levelsEstrogen levelsOvarian functionBone massNull miceSkeletal actionsFSHOsteoclast formationCirculating FSHNF-kappaBActivated MEK/ERKOsteoclastic resorptionMiceOsteoclasts
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