FLED: a full-length eccDNA detector for long-reads sequencing data
Li F, Ming W, Lu W, Wang Y, Li X, Dong X, Bai Y. FLED: a full-length eccDNA detector for long-reads sequencing data. Briefings In Bioinformatics 2023, 24: bbad388. PMID: 37930031, PMCID: PMC10632013, DOI: 10.1093/bib/bbad388.Peer-Reviewed Original ResearchConceptsLong readsNanopore long-read sequencing technologyLong-read sequencing technologiesLong-read sequencing dataShort sequence readsCancer cell line samplesNanopore long readsCis-regulatory elementsExtrachromosomal circular DNAFull-length sequenceCell linesPolymerase chain reactionCancer-related genesCell line samplesRolling Circle AmplificationCancer-related pathwaysHigh-throughput detectionSequence readsEccDNA sequencingIntact geneEccDNACancer cell linesEccDNA moleculesLinear DNARegulatory potency
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