2024
PET Imaging of Kappa Opioid Receptors in Socially Housed Female and Male Monkeys: Effects of Chronic Cocaine Self-Administration
Johnson B, Nader S, Sai K, Li S, Huang Y, Nader M. PET Imaging of Kappa Opioid Receptors in Socially Housed Female and Male Monkeys: Effects of Chronic Cocaine Self-Administration. Drug And Alcohol Dependence 2024, 260: 109961. DOI: 10.1016/j.drugalcdep.2023.109961.Peer-Reviewed Original ResearchCocaine use disorderKappa-opioid receptorsCocaine Self-AdministrationCocaine-induced changesCocaine SASelf-AdministrationBinding potentialPositron emission tomographySocial rank differencesChronic cocaine self-administrationSocial rankDrug-naive monkeysKappa-opioid receptor antagonistKappa-opioid receptor agonistFDA-approved pharmacotherapiesOpioid receptorsRegulation of stressPositron emission tomography imagingCocaine intakeDynorphin/KOR systemKOR systemFood pelletsUse disorderExperiment 1Brain regions
2021
Social Rank, Behavioral Phenotypes and Kappa Opioid Receptor: PET Imaging Studies of Socially Housed Female and Male Monkey Models of Cocaine Use Disorder
Johnson B, Sai K, Nader S, Li S, Huang Y, Nader M. Social Rank, Behavioral Phenotypes and Kappa Opioid Receptor: PET Imaging Studies of Socially Housed Female and Male Monkey Models of Cocaine Use Disorder. The FASEB Journal 2021, 35 DOI: 10.1096/fasebj.2021.35.s1.03412.Peer-Reviewed Original ResearchKOR systemDynorphin/KOR systemBrain regionsCocaine reinforcementKappa opioid receptor systemPET imagingCocaine overdose deathsPositron emission tomography studyOpioid receptor systemKappa-opioid receptorsRecent positron emission tomography (PET) studyNonhuman primate modelEmission tomography studiesStress-induced relapseChronic social stressEffects of drugsCocaine use disorderPET imaging studiesBehavioral phenotypesAgonist tracersCocaine acquisitionSocial behaviorDynorphin levelsOpioid receptorsPrimate model
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