2015
Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation
Estacion M, Vohra BP, Liu S, Hoeijmakers J, Faber CG, Merkies IS, Lauria G, Black JA, Waxman SG. Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation. Journal Of Neurophysiology 2015, 114: 1554-1564. PMID: 26156380, PMCID: PMC4561630, DOI: 10.1152/jn.00195.2015.Peer-Reviewed Original ResearchConceptsSmall fiber neuropathyDRG neuronsNav1.7 mutationCell bodiesDorsal root ganglion neuronsDRG cell bodiesModes of NCXIntraepidermal nerve fibersVoltage-gated sodium channel Nav1.7Sodium/calcium exchangerDegeneration of neuritesSodium channel Nav1.7Levels of intracellularTreatment of WTAxonal degenerationGanglion neuronsFunction missense mutationsNerve fibersAxon degenerationChannel Nav1.7Reverse NCXCalcium exchangerNav1.7DegenerationNeurons
2008
Reg-2 expression in dorsal root ganglion neurons after adjuvant-induced monoarthritis
Averill S, Inglis JJ, King VR, Thompson SW, Cafferty WB, Shortland PJ, Hunt SP, Kidd BL, Priestley JV. Reg-2 expression in dorsal root ganglion neurons after adjuvant-induced monoarthritis. Neuroscience 2008, 155: 1227-1236. PMID: 18652880, DOI: 10.1016/j.neuroscience.2008.06.049.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArthritis, ExperimentalGanglia, SpinalGene ExpressionGlial Cell Line-Derived Neurotrophic FactorIndolesLectinsLeukemia Inhibitory FactorLithostathineMaleNeuronsProto-Oncogene Proteins c-retRatsRats, WistarReceptor, trkAReceptors, Purinergic P2Receptors, Purinergic P2X3Substance PTime FactorsConceptsGlial cell line-derived neurotrophic factorDorsal root ganglion neuronsNerve growth factorDRG neuronsLeukemia inhibitory factorReg-2Ganglion neuronsLectin Griffonia simplicifolia IB4Line-derived neurotrophic factorDRG cell bodiesDorsal horn cellsCentral axon terminalsSchwann cell mitogensGriffonia simplicifolia IB4IB4 populationDorsal hornNerve injuryHorn cellsIntrathecal deliveryNeurotrophic factorSubstance PSympathetic neuronsSpinal cordInduced monoarthritisRat model
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply