2025
Notch1 Signalling Is Downregulated by Aerobic Exercise, Leading to Improvement of Hepatic Metabolism in Obese Mice
Gaspar R, Macêdo A, Nakandakari S, Muñoz V, Abud G, Vieira R, de Sousa Neto I, Pavan I, da Silva L, Simabuco F, da Silva A, Salgado W, Marchini J, Nonino C, Cintra D, Ropelle E, Pajvani U, de Freitas E, Pauli J. Notch1 Signalling Is Downregulated by Aerobic Exercise, Leading to Improvement of Hepatic Metabolism in Obese Mice. Liver International 2025, 45: e70068. PMID: 40078075, DOI: 10.1111/liv.70068.Peer-Reviewed Original ResearchConceptsNotch1 signalingAerobic exerciseRegulation of hepatic glucoseObese miceImpact of aerobic exerciseEffects of Notch1 signalingAerobic exercise trainingMTORC1 pathway activationNotch1 pathwayObese individualsTissue of obese miceCross-sectional studyNotch1 mRNA levelsMitochondrial respirationExercise trainingLivers of obese individualsTreadmill runningGluconeogenic enzymesHepG2 cell lineLipid accumulationTraining groupHepatic glucoseHepatic metabolismNotch1 proteinPathway activation
2021
Time‐restricted feeding combined with aerobic exercise training can prevent weight gain and improve metabolic disorders in mice fed a high‐fat diet
Vieira R, Muñoz V, Junqueira R, de Oliveira F, Gaspar R, Nakandakari S, de Oliveira Costa S, Torsoni M, da Silva A, Cintra D, de Moura L, Ropelle E, Zaghloul I, Mekary R, Pauli J. Time‐restricted feeding combined with aerobic exercise training can prevent weight gain and improve metabolic disorders in mice fed a high‐fat diet. The Journal Of Physiology 2021, 600: 797-813. PMID: 33450053, DOI: 10.1113/jp280820.Peer-Reviewed Original ResearchConceptsTime-restricted feedingHigh-fat dietAerobic exercise trainingMale Swiss miceHigh-fat diet feedingFatty acid oxidationSwiss miceExercise trainingMetabolic disordersDiet feedingLiver metabolismAE trainingAcid oxidationLower serum triglyceridesHepatic lipid accumulationHepatic lipid contentImproved hepatic metabolismLipogenic gene expressionSerum triglyceridesAdiposity gainBody adiposityGlycaemic homeostasisInsulin sensitivityHepatic metabolismGlucose metabolism
2015
The blood pressure response to acute and chronic aerobic exercise: A meta-analysis of candidate gene association studies
Bruneau ML, Johnson BT, Huedo-Medina TB, Larson KA, Ash GI, Pescatello LS. The blood pressure response to acute and chronic aerobic exercise: A meta-analysis of candidate gene association studies. Journal Of Science And Medicine In Sport 2015, 19: 424-431. PMID: 26122461, DOI: 10.1016/j.jsams.2015.05.009.Peer-Reviewed Original ResearchConceptsAngiotensinogen M235TChronic aerobic exerciseDiastolic blood pressureBlood pressure changesBlood pressurePost-exercise phaseAerobic exerciseM235TAmbulatory conditionsCandidate gene association studiesBlood pressure responseAerobic exercise interventionAerobic exercise trainingGene association studiesChanges of BPMaximum oxygen consumptionOnly genetic variantExercise interventionOverweight menExercise trainingAcute exercisePressure changesSample characteristicsSystematic searchAssociation studiesAssessing the Existing Professional Exercise Recommendations for Hypertension: A Review and Recommendations for Future Research Priorities
Pescatello LS, MacDonald HV, Ash GI, Lamberti LM, Farquhar WB, Arena R, Johnson BT. Assessing the Existing Professional Exercise Recommendations for Hypertension: A Review and Recommendations for Future Research Priorities. Mayo Clinic Proceedings 2015, 90: 801-812. PMID: 26046413, DOI: 10.1016/j.mayocp.2015.04.008.Peer-Reviewed Original ResearchConceptsJoint National Committee guidelinesJoint National CommitteeBlood pressureExercise recommendationsAmerican CollegeAmerican Heart Association/American CollegeEighth Joint National Committee GuidelinesAmerican Heart Association scientific statementEighth Joint National CommitteeHypertension/European SocietySeventh Joint National CommitteeCommittee guidelinesEffective exercise interventionsSpecific lifestyle modificationsEuropean SocietyAerobic exercise trainingAerobic physical activityWork Group ReportHealth education programsNational CommitteeStrength of evidenceAdult hypertensionLifestyle modificationExercise interventionPrimary outcome
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