Cellular determinants influence the red blood cell adsorption efficiency of poly(amine-co-ester) nanoparticles
Binns T, Eaton D, Akiki D, Deschenes E, Piotrowski-Daspit A, Bracaglia L, Hendrickson J, Saltzman W. Cellular determinants influence the red blood cell adsorption efficiency of poly(amine-co-ester) nanoparticles. Science Advances 2025, 11: eadt8637. PMID: 40315323, PMCID: PMC12047439, DOI: 10.1126/sciadv.adt8637.Peer-Reviewed Original ResearchConceptsRed blood cellsDelivery of nucleic acidsOptimized adsorption protocolNanoparticle biodistributionIntravenous administrationPulmonary tissueNanoparticle platformClinical translationCellular determinantsBlood cellsVascular infusionPoly(amine-co-esterDrug delivery vehiclesAdsorption efficiencyDelivery vehiclesMembrane stiffnessStudy designAdsorption protocolNanoparticlesAdministrationNucleic acidsTissueDelivery
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply