2021
Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy
Zuo S, Sun L, Wang Y, Chen B, Wang J, Ge X, Lu Y, Yang N, Shen P. Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy. Cell Death & Disease 2021, 12: 208. PMID: 33627636, PMCID: PMC7904926, DOI: 10.1038/s41419-021-03499-w.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoatesCell LineageCoculture TechniquesGene Expression Regulation, LeukemicHumansHydrazinesJanus KinasesK562 CellsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, NudeMitogen-Activated Protein KinasesPyrazolesReceptors, ThrombopoietinSignal TransductionSTAT Transcription FactorsThrombopoiesisUmbilical CordXenograft Model Antitumor AssaysConceptsChronic myeloid leukemiaTyrosine kinase inhibitorsProgression of CMLCML cellsUC-MSCsDifferentiation therapyCurrent tyrosine kinase inhibitorsTherapeutic potentialMesenchymal stem cell treatmentAcute promyelocytic leukemia (APL) treatmentImmature white blood cellsSevere adverse effectsWhite blood cellsTrans retinoic acidStem cell treatmentStem/progenitor cellsComplete remissionTreatment regimenTumor burdenCML patientsCure rateMAPK signaling pathwaysPeripheral bloodHematopoietic stem/progenitor cellsMyeloid leukemia
2013
Molecular Pathways: Induction of Polyploidy as a Novel Differentiation Therapy for Leukemia
Krause DS, Crispino JD. Molecular Pathways: Induction of Polyploidy as a Novel Differentiation Therapy for Leukemia. Clinical Cancer Research 2013, 19: 6084-6088. PMID: 23963861, PMCID: PMC3836832, DOI: 10.1158/1078-0432.ccr-12-2604.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaAcute megakaryocytic leukemiaAcute promyelocytic leukemiaDifferentiation therapyForms of AMLSpecific hematologic malignanciesAbnormal hematopoietic cellsTrans retinoic acidPolyploidy inducersTumor burdenMyelodysplastic syndromeHematologic malignanciesEffective therapyInduction of polyploidizationMyeloid leukemiaClinical studiesPromyelocytic leukemiaMegakaryocytic leukemiaPrimary myelofibrosisTherapyLeukemiaDifferentiation of megakaryocytesRetinoic acidMalignancySuch agents
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