2011
Probing the Allosteric Mechanism in Pyrrolysyl-tRNA Synthetase Using Energy-Weighted Network Formalism
Bhattacharyya M, Vishveshwara S. Probing the Allosteric Mechanism in Pyrrolysyl-tRNA Synthetase Using Energy-Weighted Network Formalism. Biochemistry 2011, 50: 6225-6236. PMID: 21650159, DOI: 10.1021/bi200306u.Peer-Reviewed Original ResearchConceptsPyrrolysyl-tRNA synthetaseDimeric proteinFunctioning of proteinsSequence/structureAllosteric regulationAllosteric communicationAnticodon recognitionTRNA synthetasesImportant residuesAllosteric mechanismKey residuesSubtle rearrangementsProteinKey playersPyrrolysineFunctional aspectsSynthetaseResiduesAtypical enzymeGlobal perturbationsComprehensive viewComplexesStructure networkMolecular dynamics simulationsPylRS
2010
Elucidation of the conformational free energy landscape in H.pylori LuxS and its implications to catalysis
Bhattacharyya M, Vishveshwara S. Elucidation of the conformational free energy landscape in H.pylori LuxS and its implications to catalysis. BMC Molecular And Cell Biology 2010, 10: 27. PMID: 20704697, PMCID: PMC2929236, DOI: 10.1186/1472-6807-10-27.Peer-Reviewed Original ResearchConceptsFree energy landscapeConformational changesActive siteDifferent conformationsConformational free energy landscapeAutoinducer-2 productionStructure network analysisDynamics of waterBacterial quorum sensingMolecular dynamics simulationsDetailed molecular levelFree energy changeEnergy landscapeFree energy evaluationEnzyme catalysisQuorum sensingDimeric proteinSimulation trajectoriesDifferent ligandsDynamics simulationsMechanistic featuresLigandsMolecular levelInactive formMechanistic details
1999
Chloride dependence of hyperpolarization‐activated chloride channel gates
Pusch M, Jordt S, Stein V, Jentsch T. Chloride dependence of hyperpolarization‐activated chloride channel gates. The Journal Of Physiology 1999, 515: 341-353. PMID: 10050002, PMCID: PMC2269146, DOI: 10.1111/j.1469-7793.1999.341ac.x.Peer-Reviewed Original Research
1987
Cultured human endothelial cells express platelet-derived growth factor A chain.
Collins T, Pober JS, Gimbrone MA, Hammacher A, Betsholtz C, Westermark B, Heldin CH. Cultured human endothelial cells express platelet-derived growth factor A chain. American Journal Of Pathology 1987, 126: 7-12. PMID: 2433948, PMCID: PMC1899550.Peer-Reviewed Original ResearchConceptsRNA speciesSame relative abundanceHuman endothelial cellsRelative abundanceB polypeptide chainsEndothelial cellsChain transcriptsC-sis geneB-chain transcriptsPlatelet-derived growth factorExtensive structural dataTranscript speciesCultured human umbilical vein endothelial cellsB-chain expressionBovine aortic endothelial cellsHuman umbilical vein endothelial cellsDimeric proteinUmbilical vein endothelial cellsCultured vascular endothelial cellsDifferent genesPrincipal cell typesHybridization analysisPolypeptide chainVein endothelial cellsCell types
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply