Thioesters Support Efficient Protein Biosynthesis by the Ribosome
Kent A, Robins J, Knudson I, Vance J, Solivan A, Hamlish N, Fitzgerald K, Schepartz A, Miller S, Cate J. Thioesters Support Efficient Protein Biosynthesis by the Ribosome. ACS Central Science 2025, 11: 404-412. PMID: 40161951, PMCID: PMC11950863, DOI: 10.1021/acscentsci.4c01698.Peer-Reviewed Original ResearchProtein biosynthesisIn vitro translation reactionsCCA-adding enzymeEfficient protein biosynthesisAminoacyl-tRNA synthetasesTranslation machineryTranslation reactionsThioester intermediateRibosomeBiochemical reactionsEffective substrateThioesterBiosynthesisA-amino acidsTruncated tRNAsTRNATRNAsPeptide synthesisPolymer synthesisOxo-esterPrebiotic peptide synthesisSynthetaseXyloseExchange reactionFlexizymes
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