Comparison of two antibodies for immunohistochemical evaluation of epidermal growth factor receptor expression in colorectal carcinomas, adenomas, and normal mucosa
Bhargava R, Chen B, Klimstra D, Saltz L, Hedvat C, Tang L, Gerald W, Teruya‐Feldstein J, Paty P, Qin J, Shia J. Comparison of two antibodies for immunohistochemical evaluation of epidermal growth factor receptor expression in colorectal carcinomas, adenomas, and normal mucosa. Cancer 2006, 106: 1857-1862. PMID: 16532444, DOI: 10.1002/cncr.21782.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorPharmDx kitColorectal carcinomaStaining intensityImmunohistochemical detection of epidermal growth factor receptorEpidermal growth factor receptor statusEpidermal growth factor receptor expressionIntensity scoresGrowth factor receptor expressionScore 1Intensity of positive stainingDetection of epidermal growth factor receptorMedian staining intensityAnti-EGFR therapyMetastatic colorectal carcinomaScore categoriesSelection of patientsAutomated image-analysis systemGrowth factor receptorClassification of tumorsManual scoringEGFR-negativeAnti-EGFRReceptor expressionPharmDx
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