2025
Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans
Hart T, Cui Y, Telford S, Marín-López A, Calloway K, Dai Y, Matias J, DePonte K, Jaycox J, DeBlasio M, Hoornstra D, Belperron A, Cibichakravarthy B, Johnson E, Alameh M, Dwivedi G, Hovius J, Bockenstedt L, Weissman D, Ring A, Fikrig E. Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans. Science Translational Medicine 2025, 17: eads9207. PMID: 40138454, PMCID: PMC12067475, DOI: 10.1126/scitranslmed.ads9207.Peer-Reviewed Original ResearchConceptsTick antigensTick resistanceVector of tick-borne pathogensAcquired tick resistanceTick-borne pathogensIxodes scapularis</i>Tick feedingAntitick vaccinesDetectable antibody responseGuinea pigsTicksTick bitesAntigen cocktailPigsPrimary vectorFeedingAntibody responseHumoral responseImmunogen candidateAntigenLyme diseaseImmunoglobulin GRepeated exposureIxodesNorth America
2023
Revaccination of patients with systemic lupus erythematosus or rheumatoid arthritis without an initial COVID-19 vaccine response elicits seroconversion in half of the patients.
Ammitzbøll C, Thomsen M, Andersen J, Jensen J, Bayarri-Olmos R, Garred P, Hermansen M, Johannsen A, Larsen M, Mistegaard C, Mikkelsen S, Nielsen L, Olesen R, Pérez-Alós L, Vils S, Szabados F, Søgaard O, Tolstrup M, Erikstrup C, Hauge E, Troldborg A. Revaccination of patients with systemic lupus erythematosus or rheumatoid arthritis without an initial COVID-19 vaccine response elicits seroconversion in half of the patients. Clinical And Experimental Rheumatology 2023, 42: 157-165. PMID: 37877429, DOI: 10.55563/clinexprheumatol/orpp04.Peer-Reviewed Original ResearchT cell responsesDetectable antibody responseBlood donorsSARS-CoV-2Antibody responseB cellsRheumatic diseasesCOVID-19 vaccine responsesSARS-CoV-2 antibodiesCOVID-19 mRNA vaccinesRevaccination of patientsSystemic lupus erythematosusB cell levelsCOVID-19 vaccinationPercent of casesDetectable serological responsesSARS-CoV-2 spike proteinAntibody class switchRD cohortLupus erythematosusVaccine responsesAntibody levelsRheumatoid arthritisSpecific IgGMRNA vaccines
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