Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks
Kawiková I, Špička V, Lai J, Askenase P, Wen L, Kejík Z, Jakubek M, Valeš K, Španiel F. Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks. Frontiers In Immunology 2025, 16: 1454306. PMID: 40264776, PMCID: PMC12011847, DOI: 10.3389/fimmu.2025.1454306.Peer-Reviewed Original ResearchConceptsDevelopment of immune therapiesEVs-based therapyIatrogenic immune deficienciesRobust preclinical dataExploitation of extracellular vesiclesPsychiatric diseasesDiagnostic biomarker panelExtracellular vesiclesRecipient cell functionsImmune therapyImmune deficiencyPatient subsetsPreclinical dataFluid abnormalitiesBiomarker panelEV administrationImmune systemIntercellular communicationPrecision therapeuticsTherapyTherapeutic toolCell functionRegulatory approvalPsychiatric conditionsBrain regions
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