Heterogeneity of IL-15-expressing mesenchymal stromal cells controls natural killer cell development and immune cell homeostasis
Stecher C, Bischl R, Schmid-Böse A, Ferstl S, Potzmann E, Frank M, Braun N, Farlik M, Flavell R, Herndler-Brandstetter D. Heterogeneity of IL-15-expressing mesenchymal stromal cells controls natural killer cell development and immune cell homeostasis. Nature Communications 2025, 16: 5949. PMID: 40595636, PMCID: PMC12218584, DOI: 10.1038/s41467-025-61231-0.Peer-Reviewed Original ResearchConceptsMemory CD8+ T cellsCD8+ T cellsMature NK cellsMesenchymal stromal cellsImmune cell lineagesBone marrowNK cellsT cellsStromal cellsNatural killerBone marrows of old miceBM mesenchymal stromal cellsNatural killer cell developmentCell lineagesHematopoietic stem cellsDeletion mouse modelIL-15 expressionImmune cell homeostasisNKT cellsIL-15Old miceMouse modelConditional deletionMicroenvironmental nicheStem cells
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