Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC
Laken S, Petersen G, Gruber S, Oddoux C, Ostrer H, Giardiello F, Hamilton S, Hampel H, Markowitz A, Klimstra D, Jhanwar S, Winawer S, Offit K, Luce M, Kinzler K, Vogelstein B. Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nature Genetics 1997, 17: 79-83. PMID: 9288102, DOI: 10.1038/ng0997-79.Peer-Reviewed Original ResearchConceptsHereditary non-polyposis colorectal cancerFamilial adenomatous polyposisNon-polyposis colorectal cancerDefective mismatch repair genesFamilial colorectal cancerColorectal cancerMismatch repair genesAdenomatous polyposisFamily historyTruncating APC mutationsAshkenazi JewsI cancerCancer predispositionAPC mutationsRepair genesUnited StatesAshkenazimCancerFamilial casesAshkenaziPolyposisEncode proteinsHypermutable regionFamilyGenes
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