2024
Peptide Nucleic Acid-Mediated Regulation of CRISPR-Cas9 Specificity
Carufe K, Economos N, Glazer P. Peptide Nucleic Acid-Mediated Regulation of CRISPR-Cas9 Specificity. Nucleic Acid Therapeutics 2024, 34: 245-256. PMID: 39037032, PMCID: PMC11564683, DOI: 10.1089/nat.2024.0007.Peer-Reviewed Original ResearchPeptide nucleic acidProtospacer adjacent motifAllele-specific mannerDegree of homologyWild-type sequencePAM-proximal regionSynthetic peptide nucleic acidOff-target sitesSpacer sequencesAdjacent motifMutant allelesCas9 cuttingBase pairsCas9 activityCRISPR technologyAutosomal dominant diseaseGRNACRISPR applicationsNucleic acidsBinding positionDominant diseaseSequenceDeliberate mismatchGene therapy
1997
Distribution, diversity, and host specificity of Bartonella in rodents from the Southeastern United States.
Kosoy M, Regnery R, Tzianabos T, Marston E, Jones D, Green D, Maupin G, Olson J, Childs J. Distribution, diversity, and host specificity of Bartonella in rodents from the Southeastern United States. American Journal Of Tropical Medicine And Hygiene 1997, 57: 578-88. PMID: 9392599, DOI: 10.4269/ajtmh.1997.57.578.Peer-Reviewed Original ResearchConceptsPhylogenetic groupsHost specificityDistinct phylogenetic groupsCitrate synthase geneSpecies of PeromyscusMajor biotic communitiesSpecies of rodentsSoutheastern United StatesDegree of homologyRodent communitiesSynthase geneWild-caught rodentsBiotic communitiesSequence homologyBartonella isolatesSequence analysisBartonellaSpeciesHomologyGenotypic groupsGenotypic variantsGeographic sitesSingle siteRodentsGenes
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