Metformin reverses established lung fibrosis in a bleomycin model
Rangarajan S, Bone N, Zmijewska A, Jiang S, Park D, Bernard K, Locy M, Ravi S, Deshane J, Mannon R, Abraham E, Darley-Usmar V, Thannickal V, Zmijewski J. Metformin reverses established lung fibrosis in a bleomycin model. Nature Medicine 2018, 24: 1121-1127. PMID: 29967351, PMCID: PMC6081262, DOI: 10.1038/s41591-018-0087-6.Peer-Reviewed Original ResearchConceptsAMPK activationDeficient AMPK activationAMPK-dependent mannerSensitivity to apoptosisApoptosis-resistant myofibroblastsIdiopathic pulmonary fibrosisExperimental mouse model of lung fibrosisModel of lung fibrosisMitochondrial biogenesisApoptosis of myofibroblastsCellular bioenergeticsLung fibrosisAMPKBleomycin modelMouse model of lung fibrosisApoptosisBleomycin model of lung fibrosisResponse to tissue injuryExperimental mouse modelPathologic fibrotic processesLungs of humansPathological resultsPulmonary fibrosisBiogenesisFibrotic process
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