One-Two Punch: Combining Chemotherapy and Immunotherapy to Decrease Radiation Dose and Related Toxicity in Children and Adolescents with Nasopharyngeal Carcinoma.
Dholaria H, Tsetlina V, Simpson S, Gillies E, Eswaran N, Rodriguez-Galindo C, Schultz K, Chen K, Wu C, Krasin M, Roemer T, Christiansen H, Piao J, Laetsch T, Pashankar F, Kontny U, Gartrell R. One-Two Punch: Combining Chemotherapy and Immunotherapy to Decrease Radiation Dose and Related Toxicity in Children and Adolescents with Nasopharyngeal Carcinoma. Clinical Cancer Research 2025, of1-of9. PMID: 40445588, DOI: 10.1158/1078-0432.ccr-24-3546.Peer-Reviewed Original ResearchGerman Society of Pediatric Oncology and HematologyChildren's Oncology GroupNasopharyngeal carcinomaClinical trialsAnti-PD-1 therapyRadiation doseDecreased radiation dosePediatric clinical trialsSevere side effectsConcomitant chemotherapyAdjuvant immunotherapyInduction chemotherapyOncology GroupRelated toxicityTreated patientsExcellent survivalSide effectsChemotherapyLate effectsLong-term effectsImmunotherapyCarcinomaClinical priorityDoseResponse-adaptive
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