The Growth Hormone-IGF-1 axis is a risk factor for Long-Term Kidney Allograft Failure
Cusick M, Nair V, Fermin D, Hartman J, Beamish J, Sun Z, Zhang Z, Otto E, Menon R, Nadimidla S, Demchuk N, Shaffer K, Heeger P, Zhang W, Menon M, Kretzler M, Wiggins R, Naik A. The Growth Hormone-IGF-1 axis is a risk factor for Long-Term Kidney Allograft Failure. JCI Insight 2025, 10: e188485. PMID: 40327402, PMCID: PMC12220966, DOI: 10.1172/jci.insight.188485.Peer-Reviewed Original ResearchConceptsDeath-censored graft failureIGF-1 levelsIGF-1 exposureIGF-1Growth hormone receptorGrowth hormone-IGF-1 axisLong-term kidney allograft failureBiopsy-proven acute rejectionT cell-mediated rejectionRisk of death-censored graft failureGrowth hormone/IGF-1 axisBody surface area ratioInsulin-like growth factor-1Kidney allograft failureDeath-censored graft failure riskOutcomes of proteinuriaPost-KTx patientsKidney function declineGrowth factor-1Allograft recipientsKidney doseBiopsy resultsAcute rejectionAllograft failureKTx recipients
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