Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate-Cholesterol-PI(4,5)P2 Pathway.
Zhang H, Meng L, Liu Y, Jiang J, He Z, Qin J, Wang C, Yang M, He K, Yang J, Chen K, He Q, Tang W, Fan S, Ren C. Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate-Cholesterol-PI(4,5)P2 Pathway. The Journal Of Immunology 2023, 211: 462-473. PMID: 37326485, DOI: 10.4049/jimmunol.2200863.Peer-Reviewed Original ResearchConceptsRegulation of actin polymerizationActin polymerizationNeutrophil spreadingCell spreadingLevels of phosphatidylinositol 4,5-bisphosphatePromote actin polymerizationNeutrophil actin polymerizationPhysiological cellular functionsPhosphatidylinositol 4,5-bisphosphateCytosolic citrateSmall interfering RNA transfectionFamily proteinsSFXN5Acetyl-CoAPI(4,5)P2 levelsMitochondrial membraneSpreading neutrophilsMetabolite transportCellular functionsMorpholino injectionCellular phenotypesCitrate transporterPlasma membraneDownstream metabolic productsDecreased neutrophil recruitment
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