2015
Neuroplasticity and Predictors of Alcohol Recovery.
Seo D, Sinha R. Neuroplasticity and Predictors of Alcohol Recovery. Alcohol Research 2015, 37: 143-52. PMID: 26259094, PMCID: PMC4476600.Peer-Reviewed Original ResearchConceptsKey neural circuitsCognitive controlEmotion regulationNeurobiological literatureNeurobiological adaptationsAdrenal axis systemFuture research directionsNeuroplastic changesAlcohol recoveryNeural circuitsLimbic circuitsSignificant predictorsAutonomic nervous systemClinical implicationsNeuroplasticityRelevant clinical implicationsResearch directionsChronic alcoholismNervous systemChronic effectsPredictorsAlcoholismPhysiological responsesRecent evidenceNeuroadaptations
2014
Association of In Vivo κ-Opioid Receptor Availability and the Transdiagnostic Dimensional Expression of Trauma-Related Psychopathology
Pietrzak RH, Naganawa M, Huang Y, Corsi-Travali S, Zheng MQ, Stein MB, Henry S, Lim K, Ropchan J, Lin SF, Carson RE, Neumeister A. Association of In Vivo κ-Opioid Receptor Availability and the Transdiagnostic Dimensional Expression of Trauma-Related Psychopathology. JAMA Psychiatry 2014, 71: 1262-1270. PMID: 25229257, DOI: 10.1001/jamapsychiatry.2014.1221.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaBenzamidesCarbon RadioisotopesCase-Control StudiesCross-Sectional StudiesDepressionFemaleFunctional NeuroimagingGyrus CinguliHumansHydrocortisoneMaleNeural PathwaysPhobic DisordersPositron-Emission TomographyPsychiatric Status Rating ScalesPyrrolidinesReceptors, Opioid, kappaStress Disorders, Post-TraumaticVentral StriatumWounds and InjuriesYoung AdultConceptsUrinary cortisol levelsLoss symptomsTrauma-related psychopathologyCortisol levelsNeural circuitsDynorphin/κ-opioid receptor systemΚ-opioid receptor systemHamilton Depression Rating ScaleRating ScaleAdrenal axis systemClinician-Administered PTSD ScalePositron emission tomography studyDepression Rating ScaleHamilton Rating ScaleMechanism-based treatmentsEmission tomography studiesAcademic medical centerPositron emission tomographyKOR systemPreclinical dataTrauma-exposed adultsHigh-resolution positron emission tomographyMedical CenterMAIN OUTCOMEDepressive symptoms
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