2019
Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC
Patrick M, Stuart P, Raja K, Chi S, He Z, Voorhees J, Tejasvi T, Gudjonsson J, Kahlenberg J, Chandran V, Rahman P, Gladman D, Nair R, Elder J, Tsoi L. Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC. Frontiers In Genetics 2019, 10: 304. PMID: 31031798, PMCID: PMC6470186, DOI: 10.3389/fgene.2019.00304.Peer-Reviewed Original ResearchGenome-wide significant lociEvidence of associationGenome-wide significanceGenetics of PsAPerspective of pharmacogenomicsCell type-specificEpigenomic elementsEpigenomic informationSignificant lociH3K27ac marksPharmacogenomic resourcesRegulatory elementsGene candidatesAssociation analysisMHC regionLociPsoriatic arthritisGene expressionCutaneous-only psoriasisGenesGenetic profileWnt signalingType-specificGWASPharmacogenomics
2018
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients
Patrick M, Stuart P, Raja K, Gudjonsson J, Tejasvi T, Yang J, Chandran V, Das S, Callis-Duffin K, Ellinghaus E, Enerbäck C, Esko T, Franke A, Kang H, Krueger G, Lim H, Rahman P, Rosen C, Weidinger S, Weichenthal M, Wen X, Voorhees J, Abecasis G, Gladman D, Nair R, Elder J, Tsoi L. Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients. Nature Communications 2018, 9: 4178. PMID: 30301895, PMCID: PMC6177414, DOI: 10.1038/s41467-018-06672-6.Peer-Reviewed Original ResearchConceptsPsoriasis patientsPredicting PsAGenetic architectureGenetic markersGenetic signaturesComputational pipelineGenetic differencesPsoriatic arthritis developmentChronic musculoskeletal conditionsCutaneous-only psoriasisArea under the receiver operating curveReceiver operating curvePSC patientsPsA riskPsoriasis subtypesPsoriatic patientsArthritis developmentPsoriatic arthritisPsoriasisPatientsConditional inference forestsShrinkage discriminant analysisPSAMusculoskeletal conditionsOperating curve
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