2021
Chemosaturation with Percutaneous Hepatic Perfusion: Outcome and Safety in Patients with Metastasized Uveal Melanoma
Dewald C, Hinrichs J, Becker L, Maschke S, Meine T, Saborowski A, Schönfeld L, Vogel A, Kirstein M, Wacker F. Chemosaturation with Percutaneous Hepatic Perfusion: Outcome and Safety in Patients with Metastasized Uveal Melanoma. RöFo 2021, 193: 928-936. PMID: 33535258, DOI: 10.1055/a-1348-1932.Peer-Reviewed Original ResearchConceptsDisease control rateMedian overall survivalPercutaneous hepatic perfusionCommon Terminology Criteria for Adverse EventsOverall response rateCS-PHPMetastasized uveal melanomaMetastatic uveal melanomaProgression-free survivalUveal melanomaAdverse eventsHepatic perfusionCardiovascular eventsHepatic progression-free survivalTransient hematologic toxicityResponse Evaluation CriteriaFrequent adverse eventsResponse to therapyHepatic disease controlKaplan-Meier estimatesCases of ischemic strokeHepatic venous bloodHematologic toxicitySalvage settingOverall survival
2020
Percutaneous isolated hepatic perfusion (chemosaturation) with melphalan following right hemihepatectomy in patients with cholangiocarcinoma and metastatic uveal melanoma: peri- and post-interventional adverse events and therapy response compared to a matched group without prior liver surgery
Dewald C, Becker L, Maschke S, Meine T, Alten T, Kirstein M, Vogel A, Wacker F, Meyer B, Hinrichs J. Percutaneous isolated hepatic perfusion (chemosaturation) with melphalan following right hemihepatectomy in patients with cholangiocarcinoma and metastatic uveal melanoma: peri- and post-interventional adverse events and therapy response compared to a matched group without prior liver surgery. Clinical & Experimental Metastasis 2020, 37: 683-692. PMID: 33034815, PMCID: PMC7666275, DOI: 10.1007/s10585-020-10057-9.Peer-Reviewed Original ResearchConceptsCommon Terminology Criteria for Adverse EventsPost-procedural adverse eventsCS-PHPAdverse eventsOverall survivalUveal melanomaTherapy responseHepatic perfusionLiver surgeryLiver metastases of uveal melanomaPercutaneous isolated hepatic perfusionMatched groupMetastases of uveal melanomaSeverity of adverse eventsAEs grade 3Percutaneous hepatic perfusionPeri-procedural safetyHigh tumor burdenMetastatic uveal melanomaPeri-procedural complicationsResponse to treatmentMann-Whitney U testKaplan-Meier estimatesRight hemihepatectomyWilcoxon signed-rank
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