2009
Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease
Joshi PR, Wu NP, André VM, Cummings DM, Cepeda C, Joyce JA, Carroll JB, Leavitt BR, Hayden MR, Levine MS, Bamford NS. Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease. Journal Of Neuroscience 2009, 29: 2414-2427. PMID: 19244517, PMCID: PMC2670193, DOI: 10.1523/jneurosci.5687-08.2009.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgingAnalysis of VarianceAnimalsBiophysicsCadmiumCells, CulturedCerebral CortexChromosomes, Artificial, YeastCorpus StriatumDisease Models, AnimalDopamine AgentsDose-Response Relationship, DrugElectric StimulationExcitatory Amino Acid AgentsExcitatory Postsynaptic PotentialsHumansHuntington DiseaseIn Vitro TechniquesMembrane PotentialsMiceNeural PathwaysNeuronsPyridinium CompoundsQuaternary Ammonium CompoundsStatistics, NonparametricTime FactorsTrinucleotide Repeat ExpansionConceptsYAC128 mouse modelGlutamate releaseCorticostriatal pathwayHuntington's diseaseCorticostriatal activityMouse modelSynaptic currentsMedium spiny neuronsAge-dependent alterationsGenetic neurodegenerative disorderAge-dependent changesBehavioral phenotypesSpiny neuronsCortical neuronsDisease progressionReceptor modulationSynaptic dysregulationDegenerative changesBrain slicesCorticostriatal functionPresynaptic terminalsCognitive deficitsNeurodegenerative disordersDiseaseMonths
2000
Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: evidence for cognitive impulsivity
Jentsch J, Roth R, Taylor J. Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: evidence for cognitive impulsivity. Biological Psychiatry 2000, 48: 415-424. PMID: 10978725, DOI: 10.1016/s0006-3223(00)00926-4.Peer-Reviewed Original ResearchConceptsPhencyclidine administrationObject retrieval detour taskFrontal cortical dysfunctionFrontal cortex ablationSubchronic phencyclidine administrationPerformance of trialsDrugs of abusePhencyclidine exposureSubchronic administrationIntermittent administrationCortical dysfunctionDrug withdrawalChronic consumptionDopaminergic dysfunctionBehavioral deficitsPsychotomimetic drugsCorticostriatal functionInhibitory response controlCognitive impairmentImpaired acquisitionNonhuman primatesAdministrationPhencyclidineDysfunctionInhibitory control
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply