2022
Direct Oral Anticoagulants vs Vitamin K Antagonists in Patients With Antiphospholipid Syndromes Meta-Analysis of Randomized Trials
Khairani C, Bejjani A, Piazza G, Jimenez D, Monreal M, Chatterjee S, Pengo V, Woller S, Cortes-Hernandez J, Connors J, Kanthi Y, Krumholz H, Middeldorp S, Falanga A, Cushman M, Goldhaber S, Garcia D, Bikdeli B. Direct Oral Anticoagulants vs Vitamin K Antagonists in Patients With Antiphospholipid Syndromes Meta-Analysis of Randomized Trials. Journal Of The American College Of Cardiology 2022, 81: 16-30. PMID: 36328154, PMCID: PMC9812926, DOI: 10.1016/j.jacc.2022.10.008.Peer-Reviewed Original ResearchConceptsDirect oral anticoagulantsVitamin K antagonistsVenous thromboembolic eventsArterial thrombotic eventsSubsequent venous thromboembolic eventsThrombotic antiphospholipid syndromeMajor bleedingThrombotic eventsK antagonistsOral anticoagulantsAntiphospholipid syndromeUse of DOACsMain efficacy outcomeMain safety outcomeCochrane Central RegisterAdequate allocation concealmentRandom-effects modelRandom sequence generationThromboembolic eventsCentral RegisterEfficacy outcomesArterial thrombosisControlled TrialsRandomized trialsAllocation concealment
2012
Fundamentals of randomized clinical trials in wound care: Design and conduct
Eskes AM, Brölmann FE, Sumpio BE, Mayer D, Moore Z, Ågren M, Hermans M, Cutting K, Legemate DA, Ubbink DT, Vermeulen H. Fundamentals of randomized clinical trials in wound care: Design and conduct. Wound Repair And Regeneration 2012, 20: 449-455. PMID: 22642397, DOI: 10.1111/j.1524-475x.2012.00799.x.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsClinical trialsAdequate allocation concealmentWound care interventionsPatient-oriented outcomesStrong scientific evidenceQuality of studiesConduct of futureOutcome assessorsWound care productsTreat analysisCare decision makingAllocation concealmentCare interventionsWound careLower riskAcute woundsStudy designEvidence baseTrialsScientific evidenceTreatment effectsRobust comparative studiesCareSources of bias
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