Synthesis and Biological Evaluation of an Indazole-Based Selective Protein Arginine Deiminase 4 (PAD4) Inhibitor
Tjin CC, Wissner RF, Jamali H, Schepartz A, Ellman JA. Synthesis and Biological Evaluation of an Indazole-Based Selective Protein Arginine Deiminase 4 (PAD4) Inhibitor. ACS Medicinal Chemistry Letters 2018, 9: 1013-1018. PMID: 30344909, PMCID: PMC6187405, DOI: 10.1021/acsmedchemlett.8b00283.Peer-Reviewed Original ResearchProtein arginine deiminase 4Potent PAD4 inhibitorPAD4 inhibitorsBiological evaluationCalcium-dependent enzymesTarget proteinsConversion of arginineHuman diseasesHL-60 granulocytesFold selectivityNew classCompoundsSynthesisInhibitorsSelectivityPAD3IndazoleProteinPAD1EnzymePAD2ConversionArginineDysregulationCitrullination
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