Modulation of Nitric-Oxide Synthase by Nicotine 1 1 This study was funded by grants from the American Heart Association (AHA 96-010290), the Mayo Graduate School of Medicine, and the Mayo Foundation.
Tonnessen B, Severson S, Hurt R, Miller V. Modulation of Nitric-Oxide Synthase by Nicotine 1 1 This study was funded by grants from the American Heart Association (AHA 96-010290), the Mayo Graduate School of Medicine, and the Mayo Foundation. Journal Of Pharmacology And Experimental Therapeutics 2000, 295: 601-606. PMID: 11046094, DOI: 10.1016/s0022-3565(24)38944-x.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseRecombinant endothelial nitric oxide synthaseEffects of nicotineNitric oxide synthaseAortic endothelial cellsNitric oxideInducible NOSNeuronal NOSEndothelium-derived nitric oxideEndothelial cellsEndothelium-dependent relaxationCalcium-dependent accumulationPresence of nicotineUntreated dogsNicotine administrationM nicotineNOS activityNicotine doseNOSNicotineCitrulline accumulationInconsistent findingsConcentration of NADPHCitrullineAccumulation of citrulline
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