2025
Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology
Davis C, Khan Y, Toikumo S, Jinwala Z, Boomsma D, Levey D, Gelernter J, Kember R, Kranzler H. Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology. Psychological Medicine 2025, 55: e138. PMID: 40336358, PMCID: PMC12094639, DOI: 10.1017/s0033291725000856.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesMultivariate genome-wide association studyGenetic architectureComorbid forms of psychopathologyHierarchical Taxonomy of PsychopathologyBivariate causal mixture modelResearch Domain CriteriaTaxonomy of PsychopathologyPsychiatric classification systemsConfirmatory factor modelsInternalizing psychopathologyComorbid formsGenetic liabilityPsychopathologyTwo-factorHierarchical taxonomyModerate genetic correlationLatent factorsAssociation studiesBiological basisHiTOPReference panelGenetic underpinningsFactor modelGenetic variants
2024
94. THE GENETIC ARCHITECTURE OF MOOD AND ANXIETY DISORDER SYMPTOMS
Schultz L, Mollon J, Jacquemont S, Almasy L, Glahn D. 94. THE GENETIC ARCHITECTURE OF MOOD AND ANXIETY DISORDER SYMPTOMS. European Neuropsychopharmacology 2024, 87: 100. DOI: 10.1016/j.euroneuro.2024.08.208.Peer-Reviewed Original ResearchEuropean ancestryPrefrontal cortexPsychiatric diagnosisGene set analysisAssociated with genesInverse-variance weighted meta-analysisICD-10 psychiatric diagnosisMeta-analysisAnxiety disorder symptomsUK Biobank (UKBMulti-ancestry meta-analysisGenome-wide significant variantsGenetic architectureRisk lociMSigDB geneChromosome 8Confirmatory factor modelsGenomic risk lociEuropean ancestry individualsAnxiety disordersDisorder symptomsMood/anxiety symptomsIdentified risk lociDopamine receptorsFrontal cortex
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