Parallel Solution-Phase Asymmetric Synthesis of α-Branched Amines
Mukade T, Dragoli D, Ellman J. Parallel Solution-Phase Asymmetric Synthesis of α-Branched Amines. ACS Combinatorial Science 2003, 5: 590-596. DOI: 10.1021/cc030016w.Peer-Reviewed Original ResearchOrganomagnesium reagentsAsymmetric synthesisMicrowave irradiationLiquid/liquid separationTert-butanesulfinyl iminesSulfonic acid resinExcellent overall yieldsSequence of reactionsSulfinamide productsOrganometallic additionBranched aminesWorkup procedureParallel synthesisSulfinyl iminesResin captureAcid/base extractionAqueous workupTitanium speciesStereoselective additionGroup cleavageHigh enantiopurityCondensation stepAmine hydrochlorideAcid resinOverall yield
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