Benzodiazepine Compounds as Inhibitors of the Src Protein Tyrosine Kinase: Screening of a Combinatorial Library of 1,4-Benzodiazepines
Ramdas L, Bunnin B, Plunkett M, Sun G, Ellman J, Gallick G, Budde R. Benzodiazepine Compounds as Inhibitors of the Src Protein Tyrosine Kinase: Screening of a Combinatorial Library of 1,4-Benzodiazepines. Archives Of Biochemistry And Biophysics 1999, 368: 394-400. PMID: 10441393, DOI: 10.1006/abbi.1999.1313.Peer-Reviewed Original ResearchConceptsProtein tyrosine kinase SrcProtein tyrosine kinasesTyrosine kinase SrcKinase SrcTyrosine kinaseSrc protein tyrosine kinaseHT-29 colon adenocarcinoma cellsMultiple inhibition analysisCompetitive inhibitorLead compoundsGrowth factor receptorColon adenocarcinoma cellsSrc activityKinase activityPeptidic substratesMechanism of bindingSrcATP-MgColony formationFactor receptorCombinatorial librariesFibroblast cellsKinaseAdenocarcinoma cellsInhibition analysis
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