Multivariate associations between structural brain changes and cognitive impairment in partially or fully remitted persons with bipolar disorder
Schandorff J, Madsen A, Damgaard V, Little B, Sankar A, Macoveanu J, Frokjaer V, Kessing L, Jørgensen M, Knudsen G, Gallagher P, Miskowiak K. Multivariate associations between structural brain changes and cognitive impairment in partially or fully remitted persons with bipolar disorder. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2025, 140: 111425. PMID: 40505718, DOI: 10.1016/j.pnpbp.2025.111425.Peer-Reviewed Original ResearchBipolar disorderGray matter volumeCognitive impairmentMatter volumeBrain structuresReduced gray matter volumeExtensive cognitive test batteryLower gray matter volumeStructural magnetic resonance imagingBrain structural alterationsCognitive test batteryPosterior cingulate regionsStructural brain changesLeft caudate nucleusCanonical correlation analysisRemitted personsVerbal learningWorking memoryExecutive functionPsychomotor speedCingulate regionsCognitive domainsRight hippocampusCognitively impaired personsBrain changes
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