Pralatrexate injection combined with oral leucovorin for mucositis management in PTCL/CTCL treatment: a multicenter phase 2 trial
Iyer S, Dakhil S, Shinohara M, Zain J, Acosta M, Foss F. Pralatrexate injection combined with oral leucovorin for mucositis management in PTCL/CTCL treatment: a multicenter phase 2 trial. Blood Neoplasia 2024, 2: 100055. PMID: 40546726, PMCID: PMC12182847, DOI: 10.1016/j.bneo.2024.100055.Peer-Reviewed Original ResearchPeripheral T-cell lymphomaT-cell lymphomaOral mucositisTreatment of relapsed/refractory peripheral T-cell lymphomaRelapsed/Refractory Peripheral T-Cell LymphomaGrade 2 oral mucositisMulticenter phase 2 trialIncidence of grade 2Cutaneous T-cell lymphomaHigh-dose methotrexate therapyCoadministration of leucovorinPhase 2 trialOpen-label trialEffect of leucovorinWeek of restAdministered 3 timesMucositis managementOral leucovorinPralatrexate dosesDose modificationMethotrexate therapyProphylactic therapyGastrointestinal mucositisSingle-armClinical benefit
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