Site‐Specific In Vivo Bioorthogonal Ligation via Chemical Modulation
Koo H, Lee J, Bao K, Wu Y, Fakhri G, Henary M, Yun S, Choi H. Site‐Specific In Vivo Bioorthogonal Ligation via Chemical Modulation. Advanced Healthcare Materials 2016, 5: 2510-2516. PMID: 27568818, PMCID: PMC5541365, DOI: 10.1002/adhm.201600574.Peer-Reviewed Original ResearchConceptsClick chemistryClick moietyEfficiency of click chemistryLow reaction efficiencyIn vivo click chemistryReaction efficiencyChemical structureBioorthogonal ligationMoietyChemistryBioorthogonal click chemistryNear-infrared fluorophoreChemical modulatorsSurface chargeTetrazinePharmacokinetic barriersLipophilicityControlled pharmacokineticsFluorophores
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