A haplotype-resolved genome assembly of the Nile rat facilitates exploration of the genetic basis of diabetes
Toh H, Yang C, Formenti G, Raja K, Yan L, Tracey A, Chow W, Howe K, Bergeron L, Zhang G, Haase B, Mountcastle J, Fedrigo O, Fogg J, Kirilenko B, Munegowda C, Hiller M, Jain A, Kihara D, Rhie A, Phillippy A, Swanson S, Jiang P, Clegg D, Jarvis E, Thomson J, Stewart R, Chaisson M, Bukhman Y. A haplotype-resolved genome assembly of the Nile rat facilitates exploration of the genetic basis of diabetes. BMC Biology 2022, 20: 245. PMID: 36344967, PMCID: PMC9641963, DOI: 10.1186/s12915-022-01427-8.Peer-Reviewed Original ResearchConceptsVertebrate Genomes ProjectGenome assemblyChromosome-level reference genome assemblyLevels of genomic resolutionGenes associated with type 2 diabetesReference genome assemblyNile ratContig N50Scaffold N50Diet-induced diabetesGenomic resolutionDuplicated GenesSegmental duplicationsGenomic featuresGenome ProjectModel organismsRobust diurnal rhythmParental haplotypesGenetic basisHouse miceMus musculusCone-rich retinaGenesN50Genetic modification
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