2017
Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOBV
Aghourian M, Legault-Denis C, Soucy J, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard M. Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOBV. Molecular Psychiatry 2017, 22: 1531-1538. PMID: 28894304, DOI: 10.1038/mp.2017.183.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBrainCase-Control StudiesCholinergic AgentsCholinergic NeuronsFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPiperidinesPositron-Emission TomographyPresynaptic TerminalsRadioactive TracersVesicular Acetylcholine Transport ProteinsConceptsMini-Mental State ExaminationStandardized uptake value ratioAlzheimer's diseaseCortical areasPresynaptic cholinergic nerve terminalsAmyloid-beta tracerNumerous cortical areasCognitive scalesCholinergic nerve terminalsUptake value ratioVesicular acetylcholine transporterMultiple cortical areasNew PET radiotracersVoxel-wise t-testsCholinergic denervationCholinergic terminalsCholinergic degenerationControl subjectsAD patientsCholinergic lossNerve terminalsAD groupHealthy subjectsAcetylcholine transporterAD subjects
1998
cDNA isolation of Alzheimer's amyloid precursor protein from cholinergic nerve terminals of the electric organ of the electric ray
IIJIMA K, LEE D, OKUTSU J, TOMITA S, HIRASHIMA N, KIRINO Y, SUZUKI T. cDNA isolation of Alzheimer's amyloid precursor protein from cholinergic nerve terminals of the electric organ of the electric ray. Biochemical Journal 1998, 330: 29-33. PMID: 9461486, PMCID: PMC1219103, DOI: 10.1042/bj3300029.Peer-Reviewed Original ResearchConceptsAlzheimer amyloid precursor proteinAmyloid precursor proteinNerve terminalsCholinergic nerve terminalsPrecursor proteinBeta-amyloid domainAPP695 isoformCholinergic neuronsElectric ray electric organCell bodiesElectric organNeuronsRay electric organPresent studyElectric lobePhosphorylation sitesCytoplasmic domainOrgansPhosphorylated formPhosphorylationProtein
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