Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells
Beard R, Zheng Z, Lagisetty K, Burns W, Tran E, Hewitt S, Abate-Daga D, Rosati S, Fine H, Ferrone S, Rosenberg S, Morgan R. Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells. Journal For ImmunoTherapy Of Cancer 2014, 2: 25. PMID: 25197555, PMCID: PMC4155770, DOI: 10.1186/2051-1426-2-25.Peer-Reviewed Original ResearchCSPG4 expressionChimeric antigen receptorChondroitin sulfate proteoglycan 4Peripheral blood lymphocytesGlioblastoma cancer stem cellsCancer stem cellsTumor antigensStem cellsCancer histologyAntigen receptorBreast cancerExpression of chondroitin sulfate proteoglycan-4CAR-transduced T cellsCell linesChimeric antigen receptor constructTriple-negative breast cancerTreatment of metastatic cancerCAR-based immunotherapyOff-tumor toxicityResected human tumorsGamma-retroviral vectorsDevelopment of immunotherapyRT-PCRTarget cell linesReverse-phase protein array
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply