2019
Transcription factor binding at Ig enhancers is linked to somatic hypermutation targeting
Dinesh RK, Barnhill B, Ilanges A, Wu L, Michelson DA, Senigl F, Alinikula J, Shabanowitz J, Hunt DF, Schatz DG. Transcription factor binding at Ig enhancers is linked to somatic hypermutation targeting. European Journal Of Immunology 2019, 50: 380-395. PMID: 31821534, PMCID: PMC7202714, DOI: 10.1002/eji.201948357.Peer-Reviewed Original ResearchConceptsActivation-induced cytidine deaminaseGene conversionSomatic hypermutationIg genesTranscription factor family membersTrans-acting factorsFactor family membersClass switch recombinationEnhancer-like sequenceRamos B cell lineIgH intronic enhancerSecondary diversificationTranscription factorsE-boxFactor bindingChIP assaysIntronic enhancerReporter assaysB cell linesSpecific DNASwitch recombinationSHM targetingIg enhancersCytidine deaminaseNovel insights
2018
Age-Related Expression of Human AT1R Variants and Associated Renal Dysfunction in Transgenic Mice
Jain S, Rana A, Jain K, Perla SK, Puri N, Kumar A. Age-Related Expression of Human AT1R Variants and Associated Renal Dysfunction in Transgenic Mice. American Journal Of Hypertension 2018, 31: 1234-1242. PMID: 30084918, PMCID: PMC6454504, DOI: 10.1093/ajh/hpy121.Peer-Reviewed Original ResearchConceptsTranscriptional regulationHap-IISingle nucleotide polymorphismsBlood pressureVivo ChIP assaysNucleotide polymorphismsTranscription factor USF2Strong transcriptional activityTg miceRenal disordersType I geneAged animalsHaplotype-dependent mannerTransgenic miceTranscriptional environmentI geneChIP assaysTranscriptional activityAssociated renal dysfunctionHigh blood pressurePro-inflammatory markersGenesPhysiological relevanceAge-related expressionAntioxidant defense
2004
RANK-L induces the expression of NFATc1, but not of NFκB subunits during osteoclast formation
Zhu L, Zaidi S, Moonga B, Troen B, Sun L. RANK-L induces the expression of NFATc1, but not of NFκB subunits during osteoclast formation. Biochemical And Biophysical Research Communications 2004, 326: 131-135. PMID: 15567162, DOI: 10.1016/j.bbrc.2004.10.212.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell DifferentiationCell LineDNA-Binding ProteinsGene Expression RegulationMembrane GlycoproteinsMiceNFATC Transcription FactorsNF-kappa BNuclear ProteinsOsteoclastsOsteogenesisProtein SubunitsRANK LigandReceptor Activator of Nuclear Factor-kappa BTranscription FactorsConceptsC-RelReal time PCRProgram of gene expressionCluster of genesTime PCRQuantitative real time PCRBeta3 integrinDay 3Transcription factorsOsteoclast formationNFkappaB familyChIP assaysGene expressionModulate expressionInterleukin-6 receptorDown-regulationUp-regulatedInsulin-like growth factor-1NFkB subunitsTartrate-resistant acid phosphataseAffymetrixNFkappaB subunitsTranscriptionGenesGrowth factor-1
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