Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines
Knudson I, Dover T, Dilworth D, Paloutzian C, Paz O, Lin J, Cho H, Gonen T, Schepartz A, Miller S. Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines. Nature Chemistry 2025, 1-12. PMID: 40962910, DOI: 10.1038/s41557-025-01935-4.Peer-Reviewed Original ResearchComplex natural productsMedicinal chemistry optimizationNatural productsAtropisomeric axisMacrocyclic architecturesChemical spacePeptide macrocyclesChemistry optimizationQuinoline pharmacophorePeptide backboneMacrocyclic peptidesB-ketoLinear peptidesTherapeutically relevant targetsQuinolineConformance controlChemical complexityPeptide ligandsBiarylMacrocycleNon-canonical amino acidsPharmacophoreDerivatizationAmideLigand
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