Single-cell transcriptomic-informed deconvolution of bulk data identifies immune checkpoint blockade resistance in urothelial cancer
Wang L, Izadmehr S, Sfakianos J, Tran M, Beaumont K, Brody R, Cordon-Cardo C, Horowitz A, Sebra R, Oh W, Bhardwaj N, Galsky M, Zhu J. Single-cell transcriptomic-informed deconvolution of bulk data identifies immune checkpoint blockade resistance in urothelial cancer. IScience 2024, 27: 109928. PMID: 38812546, PMCID: PMC11133924, DOI: 10.1016/j.isci.2024.109928.Peer-Reviewed Original ResearchScRNA-seqTumor microenvironmentUrothelial cancerRNA sequencingRNA-seq datasetsRNA-seq dataSingle-cellSingle-cell RNA sequencingMinor cell typesCohorts treated with immune checkpoint inhibitorsResistance to immune checkpoint blockadeImmune checkpoint blockade resistanceCheckpoint blockade resistanceImmune checkpoint blockadeImmune checkpoint inhibitorsTumor microenvironment heterogeneityFeatures associated with poor outcomeSpatial genomicsHuman urothelial cancerInfluence tumor progressionClinically relevant insightsCheckpoint blockadeCheckpoint inhibitorsTreatment responseCell types
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply