2003
Platelet–endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif
Gratzinger D, Barreuther M, Madri JA. Platelet–endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif. Biochemical And Biophysical Research Communications 2003, 301: 243-249. PMID: 12535670, DOI: 10.1016/s0006-291x(02)02982-0.Peer-Reviewed Original ResearchMeSH KeywordsAdherens JunctionsAmino Acid MotifsAnimalsCattleCell MovementCells, CulturedEndothelium, VascularEnzyme ActivationIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutPhosphorylationPlatelet Endothelial Cell Adhesion Molecule-1Protein BindingProtein Tyrosine Phosphatase, Non-Receptor Type 11Protein Tyrosine PhosphatasesRecombinant Fusion ProteinsTyrosineConceptsSHP-2Tyrosine phosphatase SHP-2Endothelial migrationFocal contact componentsPlatelet endothelial cell adhesion molecule-1Phosphatase SHP-2Cell-cell junctionsImmunoreceptor tyrosine-based inhibitory motifCell-substrate adhesionFocal adhesion kinaseTyrosine-based inhibitory motifPECAM-1Endothelial cellsPECAM-1 phosphorylationSelective dephosphorylationAdhesion kinaseTyrosine phosphorylationAdhesion proteinsRecombinant proteinsCytoskeletal fractionCell adhesion molecule-1Coordinated migrationInhibitory motifPhosphorylationAdhesion molecule-1
2001
Reciprocal regulation of endothelial substrate adhesion and barrier function.
Alexander J, Zhu Y, Elrod J, Alexander B, Coe L, Kalogeris T, Fuseler J. Reciprocal regulation of endothelial substrate adhesion and barrier function. Microcirculation 2001, 8: 389-401. PMID: 11781812, DOI: 10.1038/sj/mn/7800111.Peer-Reviewed Original ResearchConceptsCell-substrate adhesionFocal adhesion protein paxillinDecreased endothelial barrier functionEnhanced substrate bindingCell-cell contactProtein paxillinRegulation in vitroSubstrate bindingTyrosine phosphorylationTreated with test agentsExposure to inflammatory mediatorsProtein phosphorylationMicrovascular endothelial monolayersMM)- and timeBarrier functionReciprocal regulationCell adhesionCytoplasmic Ca2+Substrate adhesionEndothelial barrier functionTreatment of monolayersPromote localizationRemoval of H2O2ProteinPKG inhibition
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