2024
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma
Lu B, Lucca L, Lewis W, Wang J, Nogueira C, Heer S, Rayon-Estrada V, Axisa P, Reeves S, Buitrago-Pocasangre N, Pham G, Kojima M, Wei W, Aizenbud L, Bacchiocchi A, Zhang L, Walewski J, Chiang V, Olino K, Clune J, Halaban R, Kluger Y, Coyle A, Kisielow J, Obermair F, Kluger H, Hafler D. Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma. Nature Immunology 2024, 26: 82-91. PMID: 39609626, DOI: 10.1038/s41590-024-02023-4.Peer-Reviewed Original ResearchCD8+ T cellsAnti-tumor immunityRegulatory T cellsT cellsSubpopulation of CD8+ T cellsCytotoxic CD8+ T cellsHuman CD8+ T cellsTumor antigen-specific CD8Impaired anti-tumor immunityTumor antigen-specificPoor overall survivalTumor rejectionKIR expressionOverall survivalTumor antigensImmune evasionCellular mediatorsHuman cancersCD8MelanomaTumorTranscriptional programsFunctional heterogeneityImmunityPatients
2009
Protein arginine methyltransferase 1 regulates herpes simplex virus replication through ICP27 RGG-box methylation
Yu J, Shin B, Park E, Yang S, Choi S, Kang M, Rho J. Protein arginine methyltransferase 1 regulates herpes simplex virus replication through ICP27 RGG-box methylation. Biochemical And Biophysical Research Communications 2009, 391: 322-328. PMID: 19913501, DOI: 10.1016/j.bbrc.2009.11.057.Peer-Reviewed Original ResearchConceptsProtein arginine methyltransferase 1ICP27 RGG boxProtein arginine methylationArginine methylationRGG boxHerpes simplex virus type 1Arginine residuesRNA-binding activityArginine substitution mutantsArginine methyltransferase 1Gene expression in vivoRNA metabolismMethylation sitesSubcellular localizationSubstitution mutantsCellular processesCellular regulationExpression in vivoHerpes simplex virus replicationArginine mutationPRMT inhibitorsICP27Methyltransferase 1Cytokine signalingCellular mediators
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply