2018
Glucose metabolism mediates disease tolerance in cerebral malaria
Wang A, Huen SC, Luan HH, Baker K, Rinder H, Booth CJ, Medzhitov R. Glucose metabolism mediates disease tolerance in cerebral malaria. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 11042-11047. PMID: 30291189, PMCID: PMC6205430, DOI: 10.1073/pnas.1806376115.Peer-Reviewed Original ResearchConceptsCerebral malariaGlucose metabolismBlood-brain barrier permeabilityAlternative fuel substrateCerebral malaria modelInflammation-induced anorexiaParasitic disease malariaVehicle-treated animalsAcute inflammatory conditionsTissue-protective mechanismsPotential therapeutic targetDifferent inflammatory statesInhibition of glycolysisViral inflammationANKA infectionThrombotic complicationsInfectious inflammationInflammatory stateBacterial inflammationImmune infiltrationInflammatory conditionsInflammatory diseasesMale miceBarrier permeabilitySickness behavior
2013
Vitronectin Inhibits Efferocytosis through Interactions with Apoptotic Cells as well as with Macrophages
Bae H, Tadie J, Jiang S, Park D, Bell C, Thompson L, Peterson C, Thannickal V, Abraham E, Zmijewski J. Vitronectin Inhibits Efferocytosis through Interactions with Apoptotic Cells as well as with Macrophages. The Journal Of Immunology 2013, 190: 2273-2281. PMID: 23345331, PMCID: PMC3577940, DOI: 10.4049/jimmunol.1200625.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAnimalsAntibodiesApoptosisBronchoalveolar Lavage FluidCell CountCoculture TechniquesFemaleLipopolysaccharidesMacrophages, PeritonealMaleMiceMice, Inbred C57BLMice, KnockoutNeutrophilsPhagocytosisPlasminogen Activator Inhibitor 1Receptors, Urokinase Plasminogen ActivatorThymocytesVitronectinConceptsUrokinase-type plasminogen activator receptorApoptotic cellsEffective removal of apoptotic cellsIncubation of apoptotic cellsRemoval of apoptotic cellsPhagocytosis of apoptotic cellsSurface of apoptotic cellsIngest apoptotic cellsApoptotic target cellsPurified vitronectinSoluble urokinase-type plasminogen activator receptorEffects of vitronectinEngulfing phagocytesWild typePlasminogen activator inhibitor-1Plasminogen activator receptorVitronectinInhibit phagocytosisApoptotic neutrophilsActivator inhibitor-1Acute inflammatory conditionsInhibitory effectLPS-induced ALIVitronectin-deficientBronchoalveolar lavage
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply