Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs
Ward T, Qu P, Leung L, Zhou B, Muench K, Khechaduri A, Plastini M, Charlton C, Pattni R, Ho S, Ho M, Huang Y, Zhou P, Hallmayer J, Mourrain P, Palmer T, Zhang X, Urban A. Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs. European Journal Of Human Genetics 2025, 1-10. PMID: 40374944, PMCID: PMC12341848, DOI: 10.1038/s41431-025-01856-3.Peer-Reviewed Original ResearchCopy number variantsDNA methylation patternsGlobal reprogrammingMethylation patternsInduced pluripotent stem cellsNeuropsychiatric copy number variantsGene expressionDifferentially expressed genesInduced neuronsCell-type specific alterationsGenome-wideDNA methylomeDuplicate genotypingHuman genomeGene familyLocal genomesDNA methylationInduced pluripotent stem cell lineGenesMolecular etiologyDNAGenomePluripotent stem cellsProtocadherinTranscriptome
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