2016
The IN/OUT assay: a new tool to study ciliogenesis
Kukic I, Rivera-Molina F, Toomre D. The IN/OUT assay: a new tool to study ciliogenesis. Cilia 2016, 5: 23. PMID: 27493724, PMCID: PMC4972980, DOI: 10.1186/s13630-016-0044-2.Peer-Reviewed Original ResearchCiliary pocketCiliary transmembrane proteinsPlasma membrane invaginationsDeep plasma membrane invaginationsPrimary cilia assemblyCilia assemblyMembrane invaginationsTransmembrane proteinPrimary ciliaCellular antennaCilia lengthMolecular characterizationMost ciliaFunctional studiesCiliogenesisCiliaNew toolRPE cellsCellsAssaysAntibody accessEHD1New assayPocketConventional assays
2012
Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation
Yuan S, Li J, Diener DR, Choma MA, Rosenbaum JL, Sun Z. Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 2021-2026. PMID: 22308353, PMCID: PMC3277533, DOI: 10.1073/pnas.1112834109.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCiliaEvolution, MolecularGene Knockdown TechniquesGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHumansMovementOrgan SizeProtein BiosynthesisRheologyRibosomal Protein S6 KinasesSignal TransductionTranscription FactorsTuberous Sclerosis Complex 1 ProteinTumor Suppressor ProteinsZebrafishZebrafish ProteinsConceptsCilia lengthRibosomal protein S6 kinase 1Protein S6 kinase 1Protein synthesisLeft-right body asymmetryProtein synthesis regulationS6 kinase 1Vertebrate developmentTOR pathwayCilium sizeZebrafish developmentCilia assemblyTreatment of embryosDownstream substratesCilia morphologyEnvironmental cuesSynthesis regulationFluid flow generationKinase 1Cellular antennaHuman disordersCilia motilityUpstream inhibitorProper functionCiliary function
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