2017
Don’t let sleeping dogmas lie: new views of peptidoglycan synthesis and its regulation
Zhao H, Patel V, Helmann J, Dörr T. Don’t let sleeping dogmas lie: new views of peptidoglycan synthesis and its regulation. Molecular Microbiology 2017, 106: 847-860. PMID: 28975672, PMCID: PMC5720918, DOI: 10.1111/mmi.13853.Peer-Reviewed Original ResearchConceptsCell wall biogenesisCell wall synthesisWall biogenesisWall synthesisBacterial cell wall biogenesisCell wall synthesis processRod-shaped bacteriaBacterial cell wall synthesisSingle-molecule trackingPeptidoglycan synthesisCell wallMolecule trackingIntense research focusBiogenesisBacteriaCircumstantial evidencePowerful antibioticsFundamental questionsRegulationTechnical limitationsBiochemistryNew dataTemporal mappingSynthesisOld observations
2015
Chemical Probes Reveal an Extraseptal Mode of Cross-Linking in Staphylococcus aureus
Gautam S, Kim T, Spiegel DA. Chemical Probes Reveal an Extraseptal Mode of Cross-Linking in Staphylococcus aureus. Journal Of The American Chemical Society 2015, 137: 7441-7447. PMID: 26035224, DOI: 10.1021/jacs.5b02972.Peer-Reviewed Original ResearchConceptsCross-linking activityPenicillin-binding proteinsCell divisionPeptidoglycan synthesisCell wall biogenesisEnzyme cross-linking activityCell wall synthesisWall biogenesisModel organismsWall synthesisImportant human pathogenCell wallChemical probesEndogenous substratesHuman pathogensSpherical bacteriaPBP4Distinct modesPeripheral wallDivisionBiogenesisS. aureusOrganismsStaphylococcus aureusProtein
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