2019
Control of Bacterial Virulence through the Peptide Signature of the Habitat
Krypotou E, Scortti M, Grundström C, Oelker M, Luisi B, Sauer-Eriksson A, Vázquez-Boland J. Control of Bacterial Virulence through the Peptide Signature of the Habitat. Cell Reports 2019, 26: 1815-1827.e5. PMID: 30759392, PMCID: PMC6389498, DOI: 10.1016/j.celrep.2019.01.073.Peer-Reviewed Original ResearchConceptsBacterial virulenceControl of bacterial virulenceFacultative intracellular bacterium Listeria monocytogenesOpp transport systemIntracellular bacterium Listeria monocytogenesBacterium Listeria monocytogenesGSH-binding siteVirulence programCo-crystallization studiesNutritional peptidesPrfAGenetic screeningTranscriptional activityOrganic N sourcesVirulenceNon-cysteine-containing peptidesSteric blockadeHost entryRegulation mechanismBinding sitesPeptide signaturesActive peptidesPeptideN sourcesOligopeptides
2012
Distinct Disulfide Isomers of μ‑Conotoxins KIIIA and KIIIB Block Voltage-Gated Sodium Channels
Khoo KK, Gupta K, Green BR, Zhang MM, Watkins M, Olivera BM, Balaram P, Yoshikami D, Bulaj G, Norton RS. Distinct Disulfide Isomers of μ‑Conotoxins KIIIA and KIIIB Block Voltage-Gated Sodium Channels. Biochemistry 2012, 51: 9826-9835. PMID: 23167564, PMCID: PMC4131687, DOI: 10.1021/bi301256s.Peer-Reviewed Original ResearchConceptsΜ-Conotoxin KIIIADisulfide connectivityCollision-induced dissociation fragmentationDisulfide isomersNuclear magnetic resonance dataNative disulfide connectivityDisulfide patternVenom-derived peptidesDisulfide bond connectivitySame disulfide connectivityOxidative foldingDissociation fragmentationMagnetic resonance dataBond connectivityMultiple disulfide bondsMinor productsMajor isomerSolution structureActive peptidesIsomersΜ-conotoxinsResonance dataKIIIAVenom of ConusDisulfide bonds
1987
Central dopamine-peptide interactions: Electrophysiological studies
Bunney B. Central dopamine-peptide interactions: Electrophysiological studies. Neuropharmacology 1987, 26: 1003-1009. PMID: 3309707, DOI: 10.1016/0028-3908(87)90079-7.Peer-Reviewed Original ResearchConceptsDA systemSelective non-peptide antagonistMidbrain DA systemsCentral DA systemsNon-peptide antagonistsPotential therapeutic valuePotential clinical interestDA neuronsDA cellsElectrophysiological studiesMental disordersTherapeutic valueEffects of peptidesSpecific receptorsAnatomical evidenceClinical interestEndogenous substancesPeptide systemBrainPhysiological activityVariety of peptidesBehavioral studiesPhysiological relevancePeptidesActive peptides
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