The role of the secretory immunological synapse in killing by CD8+ CTL
Stinchcombe J, Griffiths G. The role of the secretory immunological synapse in killing by CD8+ CTL. Seminars In Immunology 2003, 15: 301-305. PMID: 15001168, DOI: 10.1016/j.smim.2003.09.003.Peer-Reviewed Original ResearchNeoadjuvant treatment of hepatic malignancy: an oncolytic herpes simplex virus expressing IL-12 effectively treats the parent tumor and protects against recurrence-after resection
Jarnagin W, Zager J, Klimstra D, Delman K, Malhotra S, Ebright M, Little S, DeRubertis B, Stanziale S, Hezel M, Federoff H, Fong Y. Neoadjuvant treatment of hepatic malignancy: an oncolytic herpes simplex virus expressing IL-12 effectively treats the parent tumor and protects against recurrence-after resection. Cancer Gene Therapy 2003, 10: 215-223. PMID: 12637943, DOI: 10.1038/sj.cgt.7700558.Peer-Reviewed Original ResearchConceptsMicroscopic residual diseaseHerpes simplex virusParental tumorIL-12Hepatic tumorsResidual diseasePrimary treatmentTumor cellsTreatment of established tumorsOncolytic herpes simplex virusIL-12 in vitroImmune responseCD8(+) infiltrationLocal immune stimulationOncolytic HSV therapyRisk of cancer recurrenceReduce tumor recurrenceResidual tumor cellsTumor cell killingCD8(+) lymphocytesCellular immune dysfunctionGene transfer approachSignificant local immune responseIL-12 geneLocal immune response
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