Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs
Kapnick S, Stinchcombe J, Griffiths G, Schwartzberg P. Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs. The Journal Of Immunology 2017, 198: 2699-2711. PMID: 28213500, PMCID: PMC5360469, DOI: 10.4049/jimmunol.1601202.Peer-Reviewed Original ResearchConceptsInducible T-cell kinaseT-cell kinaseITK deficiencyCD8<sup>+</sup> T cell functionCD8<sup>+</sup> T cellsAcquisition of effector functionsExposure to IL-2CD8<sup>+</sup> CTLsCD8+ CTLT cell functionSusceptibility to viral infectionsCTL expansionCytolytic capacityCytolytic effectorsT cellsIL-12IL-2Effector functionsMurine CTLTCR signalingViral infectionMurine cellsDefective functionCTLCytokine signaling
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