Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia
Perez-Diez A, Wong C, Liu X, Mystakelis H, song J, Lu Y, Sheikh V, Bourgeois J, Lisco A, Laidlaw E, Cudrici C, Zhu C, Li Q, Freeman A, Williamson P, Anderson M, Roby G, Tsang J, Siegel R, Sereti I. Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia. Journal Of Clinical Investigation 2020, 130: 5326-5337. PMID: 32634122, PMCID: PMC7524466, DOI: 10.1172/jci136254.Peer-Reviewed Original ResearchConceptsAb-dependent cell-mediated cytotoxicityComplement-dependent cytotoxicityT cellsCD4 lymphopeniaICL patientsWhole cohortIdiopathic CD4 lymphopeniaLysis of CD4Multitude of autoantibodiesCell-mediated cytotoxicityNovel therapeutic targetPathogenicity of autoantibodiesClassical complement activationClassical complement pathwayCausal infectionLow CD4Anti-CD4Opportunistic infectionsAutoimmune diseasesComplement depositionImmune deficiencyConclusionOur dataHigh prevalencePatient seraCD4
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply