2014
TLR‐mediated STAT3 and ERK activation controls IL‐10 secretion by human B cells
Liu B, Cao Y, Huizinga TW, Hafler DA, Toes RE. TLR‐mediated STAT3 and ERK activation controls IL‐10 secretion by human B cells. European Journal Of Immunology 2014, 44: 2121-2129. PMID: 24737107, DOI: 10.1002/eji.201344341.Peer-Reviewed Original ResearchConceptsIL-10 productionIL-10-producing B cellsB cellsHuman B cellsIL-10IL-10 secretionPotent immunoregulatory cytokineType I IFNERK activationType I IFN familyInhibition of STAT3TLR-MyD88Activation of STAT3Immunoregulatory cytokinesTLR signalingPotent productionMouse modelI IFNCD40 ligationAntibody productionTLRSTAT3 pathwayIFNIFN familyPotential target
2006
CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL‐medicated osteoclastogenesis: Evidence of NF‐κB–dependent, CD40‐mediated bone destruction in rheumatoid arthritis
Lee H, Jeon H, Song E, Han M, Park S, Lee S, Yun H, Kim J, Kim J, Lee Y, Kim S, Kim H, Choi J, Kang I, Kim H, Yoo W. CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL‐medicated osteoclastogenesis: Evidence of NF‐κB–dependent, CD40‐mediated bone destruction in rheumatoid arthritis. Arthritis & Rheumatism 2006, 54: 1747-1758. PMID: 16736517, DOI: 10.1002/art.21873.Peer-Reviewed Original ResearchMeSH KeywordsArthritis, RheumatoidCarrier ProteinsCD40 AntigensCells, CulturedFibroblastsHumansI-kappa B KinaseI-kappa B ProteinsMembrane GlycoproteinsMitogen-Activated Protein Kinase 1NF-kappa BNF-KappaB Inhibitor alphaOsteoclastsp38 Mitogen-Activated Protein KinasesRANK LigandReceptor Activator of Nuclear Factor-kappa BReverse Transcriptase Polymerase Chain ReactionSynovial MembraneConceptsRheumatoid arthritis synovial fibroblastsRANKL expressionCD40 ligationSynovial fibroblastsT cellsIkappaB-alphaNF-kappaBPeripheral blood mononuclear cellsTumor necrosis factor alphaTartrate-resistant acid phosphatase (TRAP) stainingERK 1/2CD40-CD40L interactionBlood mononuclear cellsRheumatoid synovial fibroblastsArthritis synovial fibroblastsNecrosis factor alphaP38 MAPKReverse transcription-polymerase chain reactionResorption pit formationNF-kappaB inhibitorTranscription-polymerase chain reactionFormation of osteoclastsNF-kappaB activationAcid phosphatase stainingL cells
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