2018
Synthesis of Azolo[1,3,5]triazines via Rhodium(III)-Catalyzed Annulation of N‑Azolo Imines and Dioxazolones
Hoang GL, Halskov K, Ellman JA. Synthesis of Azolo[1,3,5]triazines via Rhodium(III)-Catalyzed Annulation of N‑Azolo Imines and Dioxazolones. The Journal Of Organic Chemistry 2018, 83: 9522-9529. PMID: 29947517, PMCID: PMC6097942, DOI: 10.1021/acs.joc.8b01249.Peer-Reviewed Original ResearchConceptsH bondsAlkyl substituentsHeteroaromatic aldehydesH amidationCatalyzed AnnulationGood yieldsIminesAmidating reagent
2014
A Lewis Acid Catalyzed Annulation to 2,1-Benzisoxazoles
Otley KD, Ellman JA. A Lewis Acid Catalyzed Annulation to 2,1-Benzisoxazoles. The Journal Of Organic Chemistry 2014, 79: 8296-8303. PMID: 25157596, PMCID: PMC4156248, DOI: 10.1021/jo5015432.Peer-Reviewed Original ResearchConceptsInitial mechanistic investigationsLewis Acid‐Catalyzed AnnulationFriedel-Crafts cyclizationConvergent routeSubstrate scopeReaction intermediatesCompound classesGlyoxylate estersCatalyzed AnnulationO-selectivityUmpolung additionMechanistic investigationsConvenient conditionsHigh yieldsAnnulationBenzisoxazoleDeveloped methodNitrosoarenesNitrosobenzeneCyclizationNew typeIntermediatesSynthesisReactionEsters
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